Endocrine Abstracts

Introduction: Immune tumor microenvironment plays a key role in tumors’ growth and metastatic spread, while its role in the heterogeneous field of neuroendocrine neoplasms (NENs) remains unclear. There is evidence that tumor progression in NENs is promoted by an immunosuppressed microenvironment created by a plethora of infiltrating immune cells. Changes in circulating leukocyte and peripheral blood mononuclear cell (PBMC) subpopulations can mirror the local alteration of...

Context: Acromegaly is associated with several metabolic and cardio-respiratory comorbidities, with a relative increase in the last years of cancer mortality. Although the GH/ IGF-1 axis has long been supposed to play a role on immune modulation, immune function in acromegaly is poorly known.Objective: This observational, prospective, single site, pilot study (NCT05069324) aims to analyse peripheral blood mononuclear cells (PBMCs) subpopulations in acrom...

Introduction and Objectives of the Study: Combined oral contraceptives (COCs) are frequently prescribed for fertility control, however sexual dysfunction has been reported as a common side effect. In 2020, a novel progestin-only pill containing Drospirenone (DRSP) was approved as an oral contraceptive. To date, here is a notable dearth of data on the impact of DRSP on sexual function and impact on hormones, particularly regarding steroids. This study aims to investigate the po...

Background: Glucocorticoids (GC) are potent entrainers of the circadian clock, however their effect on biological rhythms in human chronic exposure have been poorly studied. Endogenous hypercortisolism (Cushing’s Syndrome, CS) is a rare condition, in which circadian disruption is sustained by a tumorous source of GC excess, offering the unique opportunity to investigate the in vivo chronic effects of GC.Methods: In a 12-month prospective mu...